Vol. 1 No. 2 (2025): JPEPT
Articles

EXPLORING THE ANTIDIABETIC POTENTIAL OF LANGSAT (Lansium Domesticum L.): A COMBINED EXTRACT APPROACH IN VIVO

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  • Juliana Handyka Rosanty Hutasoit,
  • Andi Zsazsa Rafiatul Muklis,
  • Nur Mahdi
Juliana Handyka Rosanty Hutasoit
STIKES DARUL AZHAR BATULICIN
Andi Zsazsa Rafiatul Muklis
Stikes Darul Azhar Batulicin
Nur Mahdi
Universitas Lambung Mangkurat

Published 2025-07-18

Keywords

  • DM, Glucose, Lansium domesticum, Langsat, Extract
Copyright (c) 2025 Juliana Handyka Rosanty Hutasoit, Andi Zsazsa Rafiatul Muklis, Nur Mahdi

Abstract

Diabetes Mellitus is a chronic condition caused by increased blood glucose levels due to the body no longer being able to produce enough insulin hormone or use insulin effectively. Traditional medicine has long used Langsat, a native plant of Indonesia. Langsat is widely used by the community in treating various diseases, including as a worm medicine, fever medicine, diarrhoea medicine, and cancer medicine. This study aims to find out how well a mix of antidiabetics works with EKDL (Lansium domesticum L) in lowering blood sugar levels in male white mice (Mus musculus) and to figure out the best dose of EKDL for reducing blood sugar in the mice. Experimental research method using 35 white male mice divided into 7 groups, each group containing 5 mice, namely negative control, positive control, EK, ED, EKKDL 1:1, EKKDL 2:1, and EKKDL 1:2. The results of the ANOVA test of the EKKDL dose 1:2 (200 mg / 240 mg / kgBW) were effective in reducing blood sugar levels in mice. Analysis of blood sugar level data of mice using paired T-tests and post hoc. The results of the paired t-test showed a significant difference in blood sugar levels after treatment (p <0.005) and the results of the post hoc test showed that there was a significant difference (p < 0.005) and there was no significant difference (p > 0.005) between all EKKDL in reducing blood sugar levels in mice. The combination of langsat skin and leaf extract (Lansium domesticum L.) has effectiveness in reducing blood sugar levels in experimental animals.

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References

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